Application

Used to detect/quantify: Ghrelin

General description

Circulating ghrelin is a multifunctional hormone secreted primarily by the stomach. Originally found as an endogenous ligand for the growth hormone secretagogue receptor, it is also an appetite-stimulating hormone in the regulation of energy homeostasis. It consists of 28 amino acids and the n-octanoylation of serine-3 position is necessary for its bioactivity. Long considered a key player in obesity, ghrelin may also play a role in maintaining the balance between insulin and glucose and the development of diabetes. The spike in insulin secretion occurring after eating usually correlates with a dip in ghrelin production. Researchers determined that in rat models of uncontrolled diabetes, food intake still suppressed ghrelin concentrations in the blood, but only approximately half as effectively as when insulin was present.

Millipore is pleased to offer a new Rat/Mouse Ghrelin (Active) ELISA kit for the quantification of active ghrelin in rat and mouse serum or plasma samples. Each kit is sufficient to measure 39 unknown samples in duplicate.

Other Notes

Please contact Technical Service for linearity of dilution.

Specificity

Rat/Mouse Ghrelin (Active) - 100%
Rat/Mouse "Des-Octanoyl" Ghrelin - 0%
Canine Ghrelin (Active) - 111%
Porcine Ghrelin (Active) - 98%